For MMP, the missile has a fibre-optic datalink which relays imagery back to the launcher. One could imagine any sort of target cuing from a visual description, through to target GPS co-ordinates. For NLOS engagements, it can be lofted then lock-on-after-launch.
The second iteration of Spike LR appears to have an IMU to allow for the latter type of targeting. Presumably one flies out to wards the target coordinates and then the solution is refined by the operator.
Essentially, these two seem to be very similar, although the second gen Spike LR has a longer declared range, which might be because it is notably lighter.